1614 Santorio Santorio publishes weighing experiments The physician's measurements on his own body help establish quantitative physiology and metabolism research. 1767 John Hunter inoculates himself Hunter self-experiments with venereal matter in an attempt to resolve whether gonorrhea and syphilis are the same disease. 1800 Humphry Davy tests nitrous oxide on himself Davy repeatedly inhales nitrous oxide and records its effects, helping frame later anesthetic interest. 1865 Friedrich Sertürner and others inspire drug self-testing traditions 19th-century pharmacology increasingly accepts the researcher as an initial test subject for potent compounds. August 27, 1885 Daniel Alcides Carrión is inoculated with verruga material The Peruvian medical student begins the fatal experiment that links Oroya fever and verruga peruana. October 5, 1885 Carrión dies from the experiment His death turns him into a medical martyr and gives the disease lasting historical association with his name. 1898 Max von Pettenkofer drinks cholera bacilli The hygiene pioneer self-experiments to challenge bacteriological claims about cholera causation. August 1900 Jesse Lazear lets infected mosquitoes bite him A Yellow Fever Commission member exposes himself while testing the mosquito transmission hypothesis. September 25, 1900 Jesse Lazear dies of yellow fever Lazear's death becomes one of the starkest examples of fatal self-experimentation in modern medicine. 1929 Werner Forssmann threads a catheter into his own heart The young German physician demonstrates cardiac catheterization on himself, a landmark in clinical cardiology. 1930 Forssmann publishes the result His self-experiment enters the medical literature despite institutional backlash. 1943 Albert Hofmann accidentally absorbs LSD Hofmann begins the sequence of famous self-observations that reveal LSD's extraordinary psychoactive power. April 19, 1943 Hofmann undertakes the first intentional LSD trip His bicycle ride after deliberate self-dosing becomes one of the most famous episodes in laboratory history. 1954 Jonas Salk tests polio vaccine on himself and family Salk uses personal exposure to signal confidence in the vaccine before its wider rollout. c. mid 20th century CE Deliberate self-experimentation faces stronger ethical scrutiny Postwar bioethics and formal review structures make informal self-testing less central to mainstream research. 1977 J. B. S. Haldane's self-experimental legacy remains influential By the late 20th century Haldane's decompression and gas-exposure self-tests stand as classic cases in physiology lore. 1984 Barry Marshall drinks Helicobacter pylori Marshall deliberately infects himself to show that the bacterium can inflame the stomach and help cause ulcers. 1985 Marshall's self-experiment helps shift ulcer theory The dramatic demonstration strengthens the case against the old stress-and-acid orthodoxy. 2005 Marshall receives the Nobel Prize Recognition of the H. pylori discovery marks one of the clearest modern triumphs of self-experimentation. c. 21st century CE Self-experimentation persists at the margins of biotech and quantified-self culture Modern ethics boards limit many forms of self-testing, but individual researchers and biohackers continue the practice…